What if certain mutations could happen at the same time, but were really incredibly rare?
Plus not ALL mutations would be able to mix together, maybe mostly patches/piebalds + another mutation.

For example, an Achromia lion with Patches, or a Leopon with Piebald, a Dwarf with Folded Ears, maybe a Tigon with a Primal variation (or, well, technically a saber toothed tiger)...

I find the idea cute, even if it was only limited to [random mutation] + Patches or Piebald, but I understand if people don't find the idea appealing