So a first generation hybrid is a random chance mutation—and it's extremely rare.

A GMO cow or lion meat only boosts random mutation chance. It does not increase rarity, and you're not guaranteed to get a mutie at all from either. First generation hybrids are extremely rare and require either insane luck or a lot of time and effort.

As for the "human kidney," do you mean liver? You can't breed with those at all; they're not helpful for breeding.

Now, if you mean you want to breed a hybrid from an already existing hybrid, the only thing you can do is use a buffalo scrotum to guarantee a 3 cub litter so the 5% chance rolls on more cubs. No other items will help.

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So lion meat and gmos don’t stack it’s one or the other, cotton root bark on the pregnancy BEFORE you use the gmo also can help. Liver does nothing for the mutation chance but 1% fert does. Your best bet is CRB then wait for the cooldown, then cow and breed her

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